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The answer is that a genetic mutation has turned off the bodys ability to make ferritin in response to changing iron levels. But how can the bodys storage sites for iron be full without iron overflowing into other organs? Iron may accumulate to even higher levels in diseased retinas because low oxygen levels (hypoxia) or inflammation can cause cells to retain iron. Iron chelation therapy is the removal of excess iron from the body with

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special drugs. People with hhcs typically have normal tibc and TS test results but elevated serum ferritin levels (. Normally the RPE has ways to prevent iron from entering the retina when iron levels are high, but if iron export from cells is unregulated, iron may accumulate in the eye and degrade the macula. Iron contributes to the leading causes of vision loss. A liver biopsy will show that the patient does not have iron overload.

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Joshua Dunaief, professor of ophthalmology at the University of Pennsylvania School of Medicine. If an hhcs patient is falsely diagnosed with hemochromatosis, phlebotomies used to remove excess iron from the body could make the person become iron deficient. The result is hereditary hyperferritinemia cataract syndrome (hhcs an inherited condition of early-onset cataracts which could be dangerously confused with hemochromatosis (iron overload) unless a person is diagnosed using the full iron panel : Hemoglobin : the iron-containing protein in the blood that carries iron. Oftentimes the storage protein for iron, ferritin, can reach the eye instead of the mineral itself. The macula, a small portion of the retina which is responsible for sharp and detailed vision, deteriorates over time when the retinal pigment epithelium (RPE) surrounding the macula oxidizes triggering an inflammatory response. An ophthalmologist confirms diagnosis of hhcs.

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Hyperferritinemia means high ferritin in the blood). Attachment, posted on Mon, June 20, 2016 by Kayla Wiles. Deferiprone can protect the retinas of mice by entering the retina and removing iron from it, said Dunaief, whose lab is currently testing additional drugs to prevent iron accumulation in the eye. Serum ferritin : indicates the amount of iron stored in the body, via the protein ferritin. Dunaiefs research has shown that the oral iron chelator deferiprone may be a possible treatment for AMD if iron accumulation was one of the causes for its development. But too much iron or problems with utilizing, storing, or transporting iron properly can lead to vision loss in the form of conditions such as age-related macular degeneration and hyperferritinemia syndrome, according to recent research findings. Iron accumulates in the body with age because we continue to absorb it from our diets, but we excrete very little, Dunaief said. Home / Iron Blog, iron contributes to the leading causes of vision loss. Transferrin-iron saturation percentage (TS) : a measure of iron carried by the protein transferrin in the serum; represented by fasting serum iron divided by total iron binding capacity (tibc multiplied by 100. In hhcs, components of ferritin accumulate in the eye lens and crystalize disrupting the light transmission which enables a person to see.